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. 2001 Aug 1;118(2):171–182. doi: 10.1085/jgp.118.2.171

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© 2001 The Rockefeller University Press

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Single-channel Cd²+ block of R395C and R750C. (top) Representative single-channel currents after modification by 20 μM fenvalerate, elicited by voltage steps to −50 and −80 mV from a holding potential of −120 mV with 140 mM Na⁺ in the pipette. The single-channel current is reduced in the presence of 400 or 800 μM Cd²+ (middle) Single-channel current-voltage relationships for each of the mutant channels determined from three patches in the presence and absence of Cd²+. Cd²+ blocks each of the mutants in a voltage-dependent fashion. (bottom) A plot of the logarithm of the ratio of the blocked and unblocked single-channel current amplitude versus voltage gives the fractional electrical distance (δ) for Cd²+ binding.