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. 2001 Aug 1;118(2):171–182. doi: 10.1085/jgp.118.2.171

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Selectivity of the cysteine mutants with altered Cd²+ and TTX affinities. Peak inward currents (A) and current-voltage relationship (B) through R395C in the presence of different cations. (C) Plot of the ratio of the whole-cell conductance in 140 mM Li⁺, 140 mM NH₄ ⁺, 140 mM K⁺, and 70 mM Ca²+ (G_x) compared with that in 140 mM Na⁺(G_Na). The selectivity of the wild-type channel and the selectivity filter mutant K1237C are shown for comparison.