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. 2001 Nov 1;118(5):523–546. doi: 10.1085/jgp.118.5.523

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Analysis of cAMP activation data for chimeras using a thermodynamic linkage cycle. (A) Efficacies of cAMP activation for all single-channel patches in this study are plotted using the same axes as in Fig. 6 A; each solid point plots data obtained from an individual patch from a distinct oocyte. (B) BDs of four chimeras arranged at the corners of the linkage cycle. Wide arrows represent replacements of fCNG2 C-helix by rCNG5 C-helix; dashed arrows represent replacements of fCNG2 roll subdomain by rCNG5 subdomain. For each replacement, ΔΔG_sat,cAMP (defined as the change in ΔG_sat,cAMP that results from performing that replacement) is shown, in units of kJ/mol. The independence hypothesis fails because parallel sides of the cycle have different values of ΔΔG_sat,cAMP.