Table 1.

Comparison of Agonist Potencies for Human AChRs in IMR-32 and in Transfected HEK Cells

	EC50 for Cell Line
Agonist	IMR-32	α3β4	α3α5β4	α3β2	α3α5β2
ACh	59 ± 6	79 ± 8	81 ± 15	209 ± 26	121 ± 18
	n = 1.5	n = 1.5	n = 1.5	n = 1.7	n = 1.6
	(100%)	(100%)	(100%)	(100%)	(100%)
Nic	48 ± 7	56 ± 15	42 ± 5	70 ± 6	83 ± 12
	n = 1.8	n = 1.6	n = 1.6	n = 1.2	n = 1.3
	(85%)	(85%)	(100%)	(60%)	(85%)
Cyt	57 ± 3	18 ± 1	21 ± 3	47 ± 34	∼30
	n = 1.5	n = 2.7	n = 1.9	n = 1.5	n = ND
	(80%)	(75%)	(75%)	(5%)	(4%)
DMPP	16 ± 1	14 ± 1	20 ± 1	9 ± 3	8 ± 1
	n = 1.7	n = 3.7	n = 2.7	n = 1.0	n = 1.5
	(80%)	(50%)	(55%)	(110%)	(170%)

Values for EC50 are measured in micromolar units.