Myogenic tone determined in carotid (a) and mesenteric resistance arteries (b) isolated from control or mdx mice treated for two weeks with gentamicin (genta, n=10 per group). Responses to flow were then determined in mesenteric (c) and carotid arteries (d) under a pressure of 75 mmHg.
In another group of experiments, the same experiments (flow-mediated dilation) were performed in vimentin-null mice mesenteric arteries (e).
*P <0.05; two-factor ANOVA, mdx versus control (c and d) or vim+/+ versus vim−/− (e)