Effect of NO-synthesis blockade with L-NAME (LN) on flow-mediated dilation in mesenteric resistance arteries isolated from control (a) or mdx mice (b) treated for two weeks with gentamicin (genta). Data are represented as μm dilation (a and b) and as percentage inhibition of flow-mediated dilation by L-NAME (in control, c, and mdx, d, mice) (n=10 per group). NO-synthase expression, determined in carotid arteries is shown in e.
#P <0.001; two-factor ANOVA, non-treated versus gentamicin-treated mice.
*P <0.01; two-factor ANOVA, versus control.