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. 2002 Jan 1;119(1):55–68. doi: 10.1085/jgp.119.1.55

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© 2002 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Blocking effect of K⁺ conductance with 4-AP induces an inward current and recovery of H1 HC sEPSC rate reduced by L-APB. (A) Whole-cell voltage-clamp recording from an H1 HC in the dark. 20 μM L-APB induced an outward current accompanied by a reduction in sEPSC rate. Coapplication of 200 μM 4-AP induced an inward current. A voltage command pulse of 5 mV was applied every 12 s. V _h = −71 mV. (B) Time-expanded sections of the recording in A showing reduction in sEPSC rate with APB, and then some recovery with 4-AP accompanying the inward current. (C) Bar scales show mean sEPSC rate (a) and mean peak amplitude (b) changes from four cells in each pharmacological condition.