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. 2002 Jan 1;119(1):83–91. doi: 10.1085/jgp.119.1.83

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© 2002 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Recovery of Cd²⁺-bound 464C channels is prevented by depolarization. 464C channels were held at +10 mV, and current was monitored using test pulses (400 ms) to −110 mV (closed circles). Channels were blocked with Cd²⁺ (20 μM, arrow) applied during a 5-s pulse to −110 mV. Little or no spontaneous recovery occurred with Cd²⁺ washout. DMPS (1 mM, horizontal bar) application was started while the channels were held at +10 mV. Little recovery was seen upon an initial test pulse in DMPS. Subsequent test pulses in DMPS speeded up recovery, and a long pulse (8 s) to −110 mV recovered the remaining blocked channels.