Figure 2.
Characterization of the anion currents in COSphox cells. Whole-cell current families are shown in a COSphox cell in the absence (A) or in the presence (B) of the Cl− channel blocker SITS (1 mM). Identical voltage pulse families were applied (inset), with an interval of 12 s at V hold between pulses. (C) Currents recorded during voltage ramps from –100 to 80 mV in a COSphox cell at 5 mM Cl− (solid curves) or 166 mM Cl− (dashed curve), labeled in the order recorded. Records 1, 2, and 3 were obtained ∼9, 11, and 12 min after establishing whole-cell configuration, respectively.