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. 2004 Sep;124(3):273–287. doi: 10.1085/jgp.200409040

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Copyright © 2004, The Rockefeller University Press

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Figure 10. — Exogenous H₂O₂ does not fully reactivate Cl⁻ SAC after block of NADPH oxidase by DPI or AEBSF. (A) I–V relationships after Cl⁻ SAC activation by 5 min of integrin stretch (○), exposure to 60 μM DPI for 5 min with continued stretch(⋄), and then application of 500 μM H₂O₂ for 10 min in the continued presence of both integrin stretch and 60 μM DPI (♦). (B) I–V relationships in a similar experiment after Cl⁻ SAC activation by 5 min of integrin stretch (○), exposure to 500 μM AEBSF for 6 min with continued stretch (⋄), and then application of 500 μM H₂O₂ for 10 min in the continued presence of both integrin stretch and 500 μM AEBSF (♦). At +40 mV, H₂O₂ did not reactivate Cl⁻ SAC after treatment with DPI, 4 ± 2% (n = 3), and only partially reactivated Cl⁻ SAC, 31 ± 2% (n = 3; P = 0.104), after treatment with AEBSF.