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. 2004 Sep;124(3):273–287. doi: 10.1085/jgp.200409040

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Copyright © 2004, The Rockefeller University Press

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Figure 11. — Time course of tamoxifen block of H₂O₂- and stretch-induced Cl⁻ currents. Currents at +40 mV were recorded at 1-min intervals after application of 10 μM tamoxifen and were normalized by the initial current. In both cases, the time course of block was exponential, but the time constant for block of H₂O₂-induced current, 4.15 ± 0.49 min (n = 4), was slower than for stretch-induced current, 2.07 ± 0.25 min (n = 4, P < 0.01). This unexpected discrepancy can be accounted for by an H₂O₂-mediated breakdown of tamoxifen.