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. 2004 Sep;124(3):273–287. doi: 10.1085/jgp.200409040

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Copyright © 2004, The Rockefeller University Press

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Figure 5. — Catalase, which rapidly converts H₂O₂ to H₂O, inhibits activation of Cl⁻ SAC by integrin stretch. I–V relationships before (•) and after (○) 6 min of integrin stretch in the presence of 1,000 U/ml extracellular catalase, and after a 5-min washout of catalase with continued integrin stretch (□). At +40 mV, integrin stretch in the presence of catalase did not significantly activate Cl⁻ SAC; the Cl⁻ SAC elicited was 17 ± 7% (n = 4; P = 0.393) of that in the same cell after washout of catalase.