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. 2004 Sep;124(3):273–287. doi: 10.1085/jgp.200409040

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Copyright © 2004, The Rockefeller University Press

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Figure 6. — Exogenous AngII activates a Cl⁻ current in the absence of integrin stretch via NADPH oxidase. Currents before (A, Control) and after (B, AngII) a 6-min exposure to 5 nM AngII, and after block of NADPH oxidase by exposure to 60 μM DPI for 5 min in the continued presence of AngII (C, +DPI). (D) I–V relationships for A–C. AngII activated an outwardly rectifying Cl⁻ current that partially inactivated at positive potentials and reversed at E_Cl. DPI rapidly blocked the AngII-induced current and the background Cl⁻ current. At +40 mV, the AngII-induced Cl⁻ current was 0.85 ± 0.03 pA/pF (n = 4), and DPI blocked this current by 149 ± 30% (n = 4).