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. 2004 Sep;124(3):273–287. doi: 10.1085/jgp.200409040

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Copyright © 2004, The Rockefeller University Press

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Figure 9. — Time course for Cl⁻ SAC activation by H₂O₂ (500 μM) and integrin stretch and their respective steady-state I–V relationships. (A) The H₂O₂- and integrin stretch–induced currents at +40 mV were recorded at 1-min intervals and normalized by the steady-state currents to obtain the fractional activation. The time course for Cl⁻ SAC activation by H₂O₂ was exponential with a time constant of 1.78 ± 0.13 min (n = 4), equivalent to a t_1/2 of 1.24 ± 0.09 min. Cl⁻ SAC activation by integrin stretch was slower, following a sigmoidal time course with a t_1/2 of 3.5 ± 0.1 min (n = 5) (Browe and Baumgarten, 2003b). (B) Steady-state I–V relationships for the stretch- and H₂O₂-induced currents could not be distinguished.