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. 2004 Sep;124(3):239–258. doi: 10.1085/jgp.200409071

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Copyright © 2004, The Rockefeller University Press

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Figure 11. — Changes in intramembranous charge transfer accompanying SR depletion. (A) Intramembranous charge movement currents elicited by the reference pulse to −35 mV (black), or by test pulses to the same voltage, after depleting pulses of 10 ms or 1.4 s. Due to the long conditioning duration, the third record was terminated before completion of the OFF charge movement. (B) Corresponding charge transfer (time integrals Q(t)). (C) “Transfer function,” steady release flux measured from rest (i.e., full SR load) and corrected for depletion vs. Q(V) at the end of a pulse to voltage V. The two dashed vertical lines mark Q(−35 mV) transferred by the reference pulse or the test pulse after depletion. The corresponding values of release flux at these levels of charge are indicated by dashed horizontal lines, which are separated (as shown in the inset with expanded scales) by 26% of the lower value. Release flux should therefore increase by 26% due to the increase in Q. Identifier 1726.