Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2004 Oct;124(4):409–428. doi: 10.1085/jgp.200409105

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2004, The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 16. — Control of Ca²⁺ release. (Top) Actions required to explain the present results. RyR1 in blue, RyR3 in green. I, activation of RyR1 by the T membrane voltage sensor. II, activation (of RyR1 or 3) by Ca²⁺. III, inhibition by Mg²⁺. IV, basal inhibition (of either isoform) by interactions in vivo, attributed here to triadin (red) or calsequestrin (black). V, putative interchannel allosteric interaction, which could participate in the generation of sparks and/or contribute to effect IV. (Bottom) Dissociation constants derived in the present work. Values corresponding to high affinity binding of Ca²⁺ and Mg²⁺ explain results in the frog but not the rat; hence they are attributed to RyR3 exclusively. Low affinity activation by Ca²⁺ and inhibition by Mg²⁺ was observed in the rat only and is attributed to sites in its RyR1. The species names clarify these attributions in the figure.