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. 2004 Oct;124(4):301–317. doi: 10.1085/jgp.200409041

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Copyright © 2004, The Rockefeller University Press

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Figure 10. — Block of hEag1 channels by imipramine, N-methyl-imipramine, and astemizole in cell-free patches. (A and B) Successive 6-s recordings at 80 mV in the same inside-out (A) or outside-out patches (B), respectively. At the time indicated by the solid line, the substances where applied during 2.5 s at the indicated concentrations. The bath solution had, in both cases, a pH of 6.0, while the pipette solution had a pH of 7.4. (C and D) Effect of application of N-methyl-imipramine on representative inside-out (C) and outside-out (D) patches, at both external and internal pH of 7.4.