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Clusters of single channel currents and kinetic analysis of receptors harboring the hydrophobic substitutions αT148L and αT150A. Current traces obtained at the indicated ACh concentrations are shown at a bandwidth of 10 kHz. Dwell time histograms are shown with pdfs generated from the Scheme II rate constants superimposed (see Table II). The hydrophobic substitutions cause little change from wild-type receptor activation kinetics (see Figs. 2 and 4).
