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. 2004 Dec;124(6):631–640. doi: 10.1085/jgp.200409167

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Copyright © 2004, The Rockefeller University Press

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Figure 2. — Voltage-dependent block by Y³⁺. (A) Currents evoked by moderate depolarizations, recorded before Y³⁺ (left), in 1 μM Y³⁺ (middle), and following washout (right). Voltage steps were from −80 to +20 mV, in 20-mV increments. The voltage protocol is shown below the record in Y³⁺. The Y³⁺-insensitive transient outward currents at the beginning of the step are gating currents (Burgess et al., 2002); off gating currents are not visible, since channel closing (at −100 mV) is much slower than opening (at +20 mV). 2 kHz Gaussian filter. (B) Currents evoked by strong depolarizations (+40 to +200 mV, in 20-mV increments). Note effects of Y³⁺ on tail currents (arrow).