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. 2004 Dec;124(6):631–640. doi: 10.1085/jgp.200409167

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Copyright © 2004, The Rockefeller University Press

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Figure 6. — Time course of currents at +80 mV in 1 μM Y³⁺. Currents are shown with (+) vs. without (−) a 1-ms prepulse to +200 mV. The dotted lines are fits to the sum of two exponentials, with time constants constrained to be the same for both records (τ = 5.1 and 30.2 ms). With the prepulse, the channels are primarily in the open state at the start of the fit, and the current then decays by a combination of blocking and inactivation. Without the prepulse, partial relief of block is followed by inactivation. The effect of the prepulse on kinetics at +80 mV is partially visible during the brief test pulses in Fig. 5, A and C. 2 kHz Gaussian filter. Currents at +200 and −200 mV are off scale.