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. 2004 Dec;124(6):691–701. doi: 10.1085/jgp.200409128

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Copyright © 2004, The Rockefeller University Press

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Figure 1. — Activation of rNav1.4-WCW mutant Na⁺ channels. (A) Currents were evoked by 50-ms test pulses from −100 to +50 mV in 10-mV increments. (B) Normalized membrane conductance (g_m) was plotted against the voltage. g_m was calculated from the equation g_m = I_Na/(E_m − E_Na), where I_Na is the peak current, E_m is the amplitude of the voltage step, and E_Na is the estimated reversal potential of the Na⁺ current. Plots were fitted with a Boltzmann function (1/[1 + exp((V_0.5 − V)/k)]). The average midpoint voltage (V_0.5) and slope (k) were −31.7 ± 1.2 mV and 9.6 ± 1.0 mV, respectively (n = 6). Holding potential was set at −140 mV.