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. 2004 Dec;124(6):691–701. doi: 10.1085/jgp.200409128

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Copyright © 2004, The Rockefeller University Press

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Figure 3. — Block of rNav1.4-WCW mutant currents by lidocaine. (A) Representative current traces are shown at various lidocaine concentrations. Cells were depolarized by a 50-ms test pulse at +30 mV. Pulses were delivered at 60-s intervals. (B) Peak and maintained late currents at the end of the test pulse as shown in A were measured at various lidocaine concentrations. Data were normalized to the control saline response and fitted with the Hill equation. The IC₅₀ value for the peak current was 314 ± 25 μM (Hill coefficient, 0.8 ± 0.1) (▪, n = 5). For the maintained late current the IC₅₀ was 20.9 ± 3.3 μM (0.9 ± 0.1) (▴, n = 5).