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. 2004 Dec;124(6):663–677. doi: 10.1085/jgp.200409178

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Copyright © 2004, The Rockefeller University Press

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Figure 3. — Sequence alignment of COOH-terminal regions from HCN, CNG, and related channels. Sequence alignment of the COOH-terminal region includes all members of the CNG channel family (bovine CNGA1, rat CNGA2, bovine CNGA3, rat CNGA4, bovine CNGB1, murine CNGB3) and HCN channel family (murine HCN2, mouse HCN1, rat HCN3, rat HCN4), as well as SPIH (the sea urchin sperm homologue of HCN), and the human ether-a-go-go related gene (HERG) and Drosophila Eag K⁺ channels. Above the sequence alignment, the tertiary structure elements are shown: α-helices (red rectangles), β-sheets (blue arrow), and uncoiled regions (line). Residues highlighted in blue are similar. Putative salt bridge residues studied are boxed and labeled.