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. 2004 Dec;124(6):663–677. doi: 10.1085/jgp.200409178

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Copyright © 2004, The Rockefeller University Press

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Figure 7. — Thermodynamic mutant cycle analysis for CNGA1 channels. (A) Box plot of ΔG_cGMP values for CNGA1_cys-free and mutant CNGA1 channels. The dashed line indicates the median ΔG_cGMP value for CNGA1_cys-free. (B and C) Thermodynamic mutant cycles for the intersubunit salt bridge (B) and intrasubunit salt bridge (C). The letters are the amino acid abbreviations for the residues, the number indicates the residue number, and the charge of the residue is also shown. The lines indicate when a salt bridge is possible between residues with opposite charges. ΔΔΔG values were calculated from ΔG values (see materials and methods) and are shown as mean ΔΔΔG ± SEM of ΔΔΔG.