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. 2004 Dec;124(6):663–677. doi: 10.1085/jgp.200409178

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Copyright © 2004, The Rockefeller University Press

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Figure 8. — Double negative-to-positive HCN2 mutant has same phenotype as B' helix site positive-to-negative mutant. Behavior of K472E (A) and E502K+D542K (B) HCN2 channels. Currents in response to voltage pulses to −130 mV, as well as conductance–voltage relations of the normalized conductance from tail currents at −40 mV, are shown in the absence (black) and presence of saturating cAMP (red). Diagrams at the top of each column show attractive electrostatic interactions by solid lines and repulsive electrostatic interactions by dotted lines with wild-type residues as open symbols and mutant residues as shaded symbols. The GV curves are fit with a Boltzmann relation.