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DC IL-12 suppression is a long-term consequence of severe experimental sepsis. Purified splenic DCs from septic or control mice 6 weeks after surgery were stimulated with a number of TLR agonists. IL-12 and IL-10 expression was determined at the mRNA level (A) and protein level (B). Results represent 3 independent experiments. *P ≤ .05 compared with cytokine levels measured in splenic DCs from sham mice. Error bars represent SEM.
