Fig. 2.

Prevention of blood–brain barrier leakage by pantethine treatment in PbA-infected mice. (A) BBB leakage as revealed by intravenously injected Evans blue in an untreated PbA-infected mouse; in contrast the brain of an infected pantethine-treated mouse was not stained and was comparable to the uninfected. (Left) Whole brain. (Right) Frontal section. (B) Evans blue concentration in brain extracts from uninfected and PbA-infected mice, treated or untreated with pantethine (n = 4 in each group). Open bars, untreated; hatched bars, pantethine treatment. +, infected; −, uninfected. Results are means ± SD.