Table 1.

Effects of pantethine constituents on platelet reactivity

Platelets incubated with	Fibrinogen binding, % labeled platelets		Adherent platelets, %
	Without activation	With activation
Control	2.6 ± 1.1	50.4 ± 5.5	30.8 ± 3.2
Pantethine	2.9 ± 0.9	28.8 ± 7.2**	24.6 ± 2.2*
Cysteamine	3.5 ± 0.8	48.7 ± 6.1	36.5 ± 5.0
Cystamine	2.9 ± 0.9	38.9 ± 4.5*	17.0 ± 2.3**
Pantothenic acid	2.3 ± 1.2	51.6 ± 4.7	33.1 ± 4.1

Effects of reduced/oxidized pantethine constituents on platelet fibrinogen binding and platelet adhesion to collagen. Platelets were incubated with the compounds at a concentration of 1 mM for 30 min at 37°C. They were then activated with thrombin plus collagen for determination of fibrinogen binding or transferred to collagen-coated wells for adhesion assay. Values are means ± SD of quadruplet assays in each of two independent experiments. Values significantly different from the control: *, P < 0.05 and **, P < 0.01.