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Nox2 inactivation rescues the cerebrovascular dysfunction in Tg2576 mice. CBF responses to whisker stimulation (A) and topical neocortical application of acetylcholine (10 μM) (B), bradykinin (50 μM) (C), or adenosine (400 μM) (D) in young and aged WT, Nox2−/−, Tg2576, or Tg2576/Nox2−/− mice. *, P < 0.05 from young WT; #, P < 0.05 from young Tg2576; analysis of variance and Tukey's test; n = 5 per group.
