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Short-term application of ROS scavengers counteracts the cerebrovascular dysfunction in 12- to 15-month-old Tg2576 mice. Cerebrovascular responses are rescued by a 30-min neocortical application of MnTBAP (A–C) or gp91ds-tat (gp91ds) (E–G) but not by a scrambled peptide (sgp91) (E–G). Responses to adenosine are not attenuated in Tg2576 mice (D and H). *, P < 0.05 from vehicle; analysis of variance and Tukey's test; n = 5 per group. V, vehicle.
