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Brain Aβ and amyloid burden are not reduced in 12- to 15-month-old Tg2576 mice lacking Nox2. (A and B) SDS-soluble (A) and -insoluble (B) Aβ are not different in Tg2576 and Tg2576/Nox2−/− mice (P > 0.05; analysis of variance and Tukey's test; n = 12 per group). (C and D) The amyloid load is comparable between Tg2576 (C) and Tg2576/Nox2−/− mice (D). (E and F) The number of plaques (E) and plaque load (F) do not differ between Tg2576 and Tg2576/Nox2−/− mice (P > 0.05; n = 6 per group).
