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Nox2 inactivation rescues the behavioral deficits in Tg2576 mice tested in a Y maze. The reduction in novel arm entry (A), time spent in the novel arm (B), and the increase in total arm visits (C) and defecation (D) observed in Tg2576 mice are not seen in Tg2576/Nox2−/− mice. *, P < 0.05, χ2 test in A and analysis of variance and the Newman–Keul test in B–D; n = 10–15 per group.
