Fig. 4.

Effect of benzofuran derivatives on ClC-Kb. (A) Dose–response relationship of the block at 60 mV by GF-167, MT-189, and RT-93. The ratio of the current in the presence and absence of drug is plotted vs. drug concentration. The lines are drawn according to the equation reported in Materials and Methods. (B) Comparison of CLC-K isoform drug blocking affinity. Mean values of the apparent inhibition constant at 60 mV, obtained by fitting the equation reported in Methods to the inhibition data, for each indicated derivative.