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. 2008 Jan 29;105(5):1638–1643. doi: 10.1073/pnas.0709336105

Fig. 3.

Fig. 3.

Genetic perturbations of mitochondrial fission and fusion components modified the PINK1 eye overexpression phenotype. (A) Compound eye from a WT fly showing regular arrangement of ommatidia. (B) Compound eye from a fly overexpressing PINK1 showing disruption of ommatidial structure. (C) Compound eye from a fly expressing a mfn2-inverted repeat (mfn2-IR) demonstrates that perturbation of Mfn2 had no effect on eye morphology. (D–F) A heterozygous deletion that removes the drp1 gene (D), a point mutation of drp1 (E), and an inverted repeat targeting the drp1 transcript (F) all suppress the PINK1 eye overexpression phenotype. (G–I) A heterozygous mutation of opa1 (G), a deletion of the mfn2 gene (H), and an inverted repeat targeting the mfn2 transcript (I) all enhance the PINK1 eye overexpression phenotype. Genotypes: drp1Df = Df(2L)C144; opa1S3 = opa1l(2)S3475; mfn2Df = Df (1)Excel6239.