Table 1.

Variation in the down-regulation of MICA alleles by K5

Cell line, origin	Down-regulation†	Allele 1/Allele 2‡
U373, astrocytoma	+++	001/001
HMEC-1, endothelial carcinoma	+++	00201–052/00201–052
Caco-2, colon carcinoma	+++	010/010
HT29, colon carcinoma	+++	004/016
HepG2, liver carcinoma	+++	00201–052/00901–049
Jurkat, T cell leukaemia	+	00801–00804/00901–049
BJAB, B cell lymphoma	+	00801–00804/011–047
HeLa, cervical carcinoma	−	00801–00804/00801–00804
293T, kidney carcinoma	−	00801–00804/00801–008

^†Down-regulation: +++, 50–100%; +, 10–50%; −, 0–10%.

^‡MICA allele genotype follows the nomenclature at www.anthonynolan.org.uk. Ambiguous allele assignment, e.g., 00804 not distinguished from 00801, is given as 00801–00804.