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Decrease of brain volume in NL-4-KO mice. (A) Representative MRI sections of the brains of WT and NL-4-KO animals. (B–E) Results of volumetric analysis of selected brain regions in WT (n = 10) and NL-4-KO mice (n = 10). (B) Total brain, (C) cerebellum, (D) brainstem, and (E) ventricles. Data are presented as mean ± SEM. Asterisks indicate a significant change in NL-4-KO mice (P = 0.004, B; P = 0.0005, C; P = 0.01, D).
