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. 2008 Jan 10;27(2):421–432. doi: 10.1038/sj.emboj.7601975

Figure 3.

Figure 3

The accumulation of 8-oxoG in nDNA or mtDNA independently causes cell death. (A) Establishment of OGG1-null MEFs expressing both the nuclear and mitochondrial forms of hOGG1. Expression of both hOGG1 proteins was confirmed by western blotting analysis using anti-HCD. (B) Cell viability 24 h after exposure to menadione. Results from three independent experiments, each of which was run in triplicate, are presented (mean±s.d.). The Tukey–Kramer test revealed that the cell viability was significantly different between each type of MEF with 25 and 50 μM menadione (P-value<0.05) except between Nu-hOGG1 and Mt-hOGG1 MEFs with 50 μM menadione.