Table 1.

Box 1 The logics of QC

1. Preventing the deployment of aberrant protein conformers

2. Retaining precursor proteins in an environment suitable for their maturation

3. Favoring correct assembly by increasing subunit concentration

4. Reducing the risks of proteotoxicity by inhibiting aggregation and degrading terminally misfolded proteins

5. Maintaining homeostasis in the early secretory pathway

6. Developmental regulation of protein secretion (IgM, adiponectin)

7. Storing proteins for regulated secretion (plants, adipocytes)

QC, quality control.