Table 1.
Summary of the Confirmed Hits
| IC50 (μM)
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| SKI ID | Name | Scaffold | K562 | NCEB-1 | HL-60 | Jurkat | RV+ | HEK293 | FP | FLUO |
| 209325 | Hematoxylin | A | — | — | 60 | 4.7 | 59 | — | 2.7 | — |
| 209412 | 2′,2′-Bisepigallocatechin monogallate | A | — | — | — | 3.0 | — | — | 4.1 | 54 |
| 209466 | Actinonin | — | — | 46 | 22 | — | 28 | 5.5 | 1.5 | |
| 209469 | Pyrogallin | B | — | — | — | 0.24 | — | — | 5.7 | 46 |
| 209343 | Theaflavin | A/B | — | — | — | 53 | — | — | 6.1 | — |
| 209459 | Theaflavin monogallates | A/B | — | — | — | 1.3 | — | — | 7.1 | — |
| 209468 | Purpurogallin | B | — | — | — | 11 | — | — | 8.8 | — |
| 210479 | Quinalizarin | — | — | — | — | — | — | 8.9 | — | |
| 210893 | Hematein | A | — | — | — | 2.3 | — | — | 12 | — |
| 209399 | 7,8-Dihydroxyflavone | — | — | 52 | 7.5 | — | 28 | 17 | — | |
| 209392 | Irigenol | — | — | — | 3.2 | — | — | 17 | 61 | |
| 218293 | Epitheaflavin monogallate | A/B | — | — | — | 3.4 | — | — | 29 | — |
| 211431 | 3-Methoxycatechol | — | — | 7.0 | 5.5 | 11 | 28 | 31 | — | |
| 209415 | Epigallocatechin 3,5-digallate | A | — | — | — | 0.57 | — | — | 38 | — |
| 211412 | Chloranil | — | — | — | 15 | — | 19 | 48 | — | |
| 211062 | Thiram | 53 | — | 0.03 | 3.2 | 0.3 | 0.81 | — | 43 | |
The IC50 (μM) for each compound in the fluorescence polarization (FP) assay, fluorescamine (FLUO) assay, and cytotoxicity studies against a panel of cell lines is summarized. — = IC50 >100 μM.