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. 2003 Sep;122(3):365–374. doi: 10.1085/jgp.200308857

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Copyright © 2003, The Rockefeller University Press

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Figure 1. — Families of superimposed Na⁺ current traces before and after 30 μM flecainide application. Currents were evoked by 5-ms pulses to voltages ranging from −120 to +50 mV in 10-mV increments and were recorded before (A) and after 30 μM flecainide (B). The inward current evoked by a pulse to −50 mV and the outward current evoked by a pulse to 50 mV are labeled. (C) Conductance was determined from the equation g_m = I_Na/(E_m − E_Na), where I_NA is the peak current, E_m is the test voltage, and E_Na is the estimated reversal potential, and plotted against the corresponding voltage. Plots were fitted with a Boltzmann function. The average midpoint voltage (V_0.5) and slope (k) of the function for control Nav1.4 wild-type (circle, n = 5) were (in mV) −30.8 ± 1.1 and 9.9 ± 0.9, respectively, and −30.4 ± 1.4 and 8.2 ± 1.3 for the flecainide treated cell (triangle, n = 4). The holding potential was −140 mV. The β1 subunit was cotransfected with rNav1.4.