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. 2003 Sep;122(3):365–374. doi: 10.1085/jgp.200308857

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Copyright © 2003, The Rockefeller University Press

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Figure 5. — Inactivation-deficient rNav1.4-L435W/L437C/A438W Na⁺ currents before and after application of 30 μM flecainide. Superimposed current traces before (A) and after flecainide (B) were evoked by 5-ms pulses ranging from −120 to +50 mV in 10-mV increments. The inward current evoked by a pulse to −50 mV and the outward current evoked by a pulse to +50 mV are labeled. (C) Normalized conductance (g_m) plotted versus the amplitude of the 5-ms voltage step. G_m was determined as described in Fig. 1 C. Plots were fitted with a Boltzmann function. The average midpoint voltage (V_0.5) and slope (k) of the function in the control solution (open square, n = 5) were −20.2 ± 1.6 and 11.1 ± 1.4, respectively, and −20.2 ± 1.3 and 13.8 ± 1.2 for the flecainide-treated cell (closed square, n = 5).