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. 2004 May;123(5):521–531. doi: 10.1085/jgp.200409011

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Copyright © 2004, The Rockefeller University Press

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Figure 2. — The ATR dose–response relations for homomeric (CNGA1) and heteromeric (CNGA1 + CNGB1) rod CNG channels. Cyclic GMP–activated currents were measured at +100 mV before and after ATR addition. Currents were monitored for ∼1 h after ATR addition to ensure that the ATR inhibition had reached steady-state. Averaged data, plotted with SEM (error bars) were fit with the Hill equation (solid or dashed curves): I/I₀ = IC₅₀ ⁿ/(IC₅₀ ⁿ + [ATR]ⁿ), where I is current remaining at a given [ATR], I₀ is the current before ATR addition, IC₅₀ is the concentration of ATR required to achieve half maximal inhibition, and n is the Hill (cooperativity) coefficient. Filled circles, homomeric (CNGA1 only) rod channel dose–response relation for inhibition by ATR in saturating (2 mM) cGMP. Data points are averaged from 19 patches; IC₅₀ = 220 nM and n = 1.4. Open triangles, heteromeric (CNGA1 and CNGB1) rod channel dose–response relation for ATR inhibition in saturating (2 mM) cGMP. Data points are from five patches; IC₅₀ = 185 nM and n = 1.8. Open circles, homomeric (CNGA1) rod channel dose–response relation for ATR inhibition at cGMP concentrations evoking ∼7.4% activation. Data are from five patches; IC₅₀ = 20 nM and n = 1.4.