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. 2004 May;123(5):521–531. doi: 10.1085/jgp.200409011

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Copyright © 2004, The Rockefeller University Press

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Figure 4. — Time course of inhibition by 400 nM ATR in 2 mM cGMP for inside-out and outside-out, multichannel patches containing homomeric (CNGA1) rod channels. (A) Time course of inhibition for this inside-out patch is best fit with a double exponential (τ_fast = 119 s and τ_slow = 1,667 s), although patches were often fit with a single exponential. (B) The time course for outside-out patches was so much slower than for inside-out patches that very little inhibition was measured during the lifetime of the patch; for this patch, a single-exponential fit gave τ = 6,748 s, although clearly the current had not reached steady-state by the end of the record.