TABLE I.
Effects of Gd+3 on Membrane Capacitance and Conductance
| Baseline | Gd+3 | Washout | |||||
|---|---|---|---|---|---|---|---|
| 0 min | 10 min | 30 min | 60 min | 90 min | 30 min | 60 min | |
| g m/g Na, μs | |||||||
| Control n = 8 |
1.8 ± 0.4 | 1.2 ± 0.1 | 1.2 ± 0.2 | 1.1 ± 0.2 | 1.1 ± 0.2 | 1.3 ± 0.2 | 1.4 ± 0.3 |
| ENac n = 9 |
16.8 ± 3.3 | 15.7 ± 3.0 | 11.6 ± 1.9 | 6.3 ± 0.8 | 4.6 ± 0.6 | 6.5 ± 1.0 | 9.2 ± 1.6 |
| Cm, nF | |||||||
| Control n = 8 |
236 ± 11 | 235 ± 10 | 234 ± 10 | 225 ± 11 | 219 ± 12 | 213 ± 12 | 215 ± 12 |
| ENac n = 9 |
259 ± 12 | 256 ± 12 | 237 ± 10 | 218 ± 10 | 207 ± 10 | 206 ± 11 | 206 ± 10 |
Data are means ± SEM. g m refers to the conductance in control oocytes, while g Na refers to the amiloride-sensitive conductance in ENaC-expressing oocytes.