TABLE II.
Effects of Chlorpromazine on Membrane Capacitance and Conductance
| Baseline
|
[CPZ]
|
Washout
|
||||
|---|---|---|---|---|---|---|
| 0 | 10 μM | 50 μM | 100 μM | 30 min | 60 min | |
| g m/g Na, μs | ||||||
| Control n = 6 |
3.9 ± 0.7 | 3.0 ± 0.6 | 2.3 ± 0.3 | 1.9 ± 0.4 | 1.6 ± 0.4 | 1.7 ± 0.3 |
| ENac n = 9 |
15.0 ± 2.3 | 15.7 ± 2.4 | 12.1 ± 2.1 | 6.1 ± 1.3 | 4.1 ± 1.0 | 6.3 ± 1.2 |
| Cm, nF | ||||||
| Control n = 6 |
281 ± 7 | 276 ± 6 | 252 ± 8 | 199 ± 15 | 210 ± 8 | 240 ± 9 |
| ENac n = 9 |
285 ± 11 | 286 ± 12 | 258 ± 10 | 203 ± 9 | 196 ± 9 | 220 ± 12 |
Data are means ± SEM. g m refers to the conductance in control oocytes, while g Na refers to the amiloride-sensitive conductance in ENaC-expressing oocytes.