Skip to main content
. Author manuscript; available in PMC: 2008 Feb 8.
Published in final edited form as: Bioorg Med Chem. 2006 Jul 7;14(19):6525–6538. doi: 10.1016/j.bmc.2006.06.019

Scheme 2.

Scheme 2

Reagents and conditions: (a) i—Me3SiCN, ZnI2 (cat.), CH2Cl2, ii—HCl, AcOH, reflux; (b) H2, Pd/C, MeOH, 30 psi; (c) i—SOCl2, THF, DMF (cat.), ii—4-nitro-3-(trifluoromethyl)aniline (41), Et3N; (d) CSCl2, aq NaHCO3, CHCl3.