Table 2.
Incidence of Tumors in PitKO and Control Mice
| Mice | Tumors | Tumor rate | Prolactinoma | Rate | Nonprolactinomaa | Rate | |
|---|---|---|---|---|---|---|---|
| KO | 21 | 10 | 0.48 | 4 | 0.19 | 6 | 0.29 |
| Non-KO | 28 | 5 | 0.18 | 4 | 0.14 | 1 | 0.04 |
| Total | 49 | 15 | 0.31 | 8 | 0.16 | 7 | 0.14 |
| P < 0.05b | P = NS | P < 0.05b |
NS, Not significant.
a
The nonprolactinoma tumors showed the following: in the WT mouse, the tumor stained for Prl and TSH. In the KO mice, four tumors stained for Prl, TSH, and GH; one tumor stained for Prl and TSH only, and one tumor stained for Prl and GH only.
b
Comparison of KO vs. non-KO by Fisher’s exact test.