Table 1.

MN frequency in B6C3F1 mice administered S-adenosylmethionine chloride, cefuroxime, diphenolic acid, 3-amino-6-methylphenol, or pentabromodiphenyl oxide

S-Adenosylmethionine chloride
		Microscopy	Flow Cytometry
		BM	PB

Dose (mg/kg)	N¹	MN-RET/1000 RET²
0	5	0.60 ± 0.19	2.29 ± 0.11
500	5	3.60 ± 0.51^*	2.06 ± 0.11
1000	4	0.88 ± 0.13	2.38 ± 0.06
2000	4	1.63 ± 0.43	2.26 ± 0.17
Trend Test		P = 0.427	P = 0.607
CPA³	3	42.50 ± 1.54^*	23.49 ± 1.77^*
Cefuroxime
		Microscopy	Flow Cytometry
		BM	PB

Dose (mg/kg)	N	MN-RET/1000 RET
0	5	1.60 ± 0.24	2.28 ± 0.17
500	5	1.30 ± 0.37	2.22 ± 0.15
1000	4	1.38 ± 0.24	2.32 ± 0.37
2000	5	1.30 ± 0.37	2.30 ± 0.17
Trend Test		P = 0.677	P = 0.413
CPA	4	35.25 ± 1.53^*	21.34 ± 1.68^*
Diphenolic Acid
		Microscopy	Flow Cytometry
		BM	PB

Dose (mg/kg)	N	MN-RET/1000 RET
0	5	1.60 ± 0.40	2.45 ± 0.20
500	5	2.50 ± 0.76	2.31 ± 0.21
1000	5	1.50 ± 0.57	2.43 ± 0.14
2000	5	2.20 ± 0.90	2.27 ± 0.30
Trend Test		P = 0.371	P = 0.736
CPA	5	27.90 ± 4.37^*	30.56 ± 1.91^*
3-Amino-6-methylphenol
		Microscopy	Flow Cytometry
		BM	PB

Dose (mg/kg)	N	MN-RET/1000 RET
0	5	1.10 ± 0.51	2.44 ± 0.18
100	5	2.78 ± 0.60^*	2.41 ± 0.19
200	5	1.60 ± 0.56	2.06 ± 0.24
400	5	2.20 ± 0.46	2.34 ± 0.16
Trend Test		P = 0.137	P = 0.590
CPA	5	39.90 ± 4.46^*	27.99 ± 1.09^*
Pentabromodiphenyl Oxide
		Microscopy	Flow Cytometry
		BM	PB

Dose (mg/kg)	N	MN-RET/1000 RET
0	5	2.00 ± 0.42	2.59 ± 0.20
312.5	5	1.50 ± 0.32	2.16 ± 0.10
625	5	1.90 ± 0.37	2.21 ±-/12
1250	5	2.10 ± 0.19	2.33 ± 0.19
Trend Test		P = 0.327	P = 0.790
CPA	5	33.70 ± 4.14^*	31.81 ± 1.58^*

Significantly different from control (P < 0.025/3 = 0.008)

N = number of animals scored

Data presented as mean ± standard error; see Methods and Materials, Section 2.4 for analysis procedures used for microscopy-based scoring and FCM-based scoring

Cyclophosphamide, positive control administered at 50 mg/kg