Table 3.
Laboratory parameters monitored for immune recovery
| Time after transplantation | Patients younger than 50 y, n = 33 | Patients 50 y or older, n = 19 | All, n = 52 |
|---|---|---|---|
| 5 to 7 mo., no. evaluated/eligible | 24/27 | 16/17 | 40/44 |
| CD4, % | |||
| 200 or more cells/μL | 38 | 44 | 40 |
| Less than 100 cells/μL | 25 | 13 | 20 |
| PHA, % | |||
| Median | 52 | 13 | 32 |
| Less than 25% LLN | 33 | 69 | 48* |
| 11 to 12 mo., no. evaluated/eligible | 21/24 | 11/13 | 32/35 |
| CD4, % | |||
| 200 or more cells/μL | 71 | 55 | 66 |
| Less than 100 cells/μL | 10 | 9 | 9 |
| PHA, % | |||
| Median | 113 | 14 | 71 |
| Less than 25% LLN | 0 | 64 | 22† |
| 15 to 18 mo., no. evaluated/eligible | 17/23 | 10/10 | 27/33 |
| CD4, % | |||
| 200 or more cells/μL | 71 | 90 | 82 |
| Less than 100 cells/μL | 0 | 0 | 0 |
| PHA, % | |||
| Median | 129 | 37 | 100 |
| Less than 25% LLN | 6 | 44 | 20* |
| 24 mo., no. evaluated/eligible | 12/21 | 4/7 | 16/28 |
| CD4, % | |||
| 200 or more cells/μL | 83 | 75 | 81 |
| Less than 100 cells/μL | 8 | 0 | 6 |
| PHA, % | |||
| Median | 126 | 22 | 103 |
| Less than 25% LLN | 9 | 50 | 20‡ |
CD4 indicates the percentage of patients with an absolute CD4 count 200 or more or less than 100 cells/μL.
Each patient's PHA response was calculated as percentage = (patient response/LLN).
Less than 25% LLN indicates the percentage of patients with PHA responses less than 25% LLN.
*
P = .05
†
P < .01
‡
P = .14