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TDZD-8 treatment induces oxidative stress. (A) Flow cytometric overlays for mBBr fluorescence from primary AML, CLL, ALL, or normal mononuclear cells treated for 30 minutes with 20 μM TDZD-8 (black line) versus untreated controls (black line/gray filling). (B) Percentage of viability of primary AML cells pretreated with NAC (gray bars) for 1 hour before treatment with 20 μM TDZD-8. Viability was determined 24 hours after the addition of each drug. Error bars represent the SEM.
